Quantitative histopathology of liver and portal lymphnode in chronic, bovine fascioliasis

Abstract

This study reports histopathological changes of liver and associated portal lymphnodes in natural bovine fascioliasis by means of quantitative methods. Of 1000 livers of cattle examined for the presence of Fasciola hepatica and gigantica 50 randomly selected livers and associated portal lymph nodes of the infected cattle were studied. Statistically significant changes (P> 0.05) in liver parenchyma were, lobular hepatic chord fibrosis, liver cell atrophy and regeneration. congestion and edema of sin uses, increase and activation of Kupffer cells and fibrous tissue, cellular infiltration and proliferation or bile ducts in portal triads. In bile ducts, trauma, hyperplasia and regeneration of epithelia, globule leukocyte in the epithelium. glandular hyperplasia, calcium deposition, plasma cell infiltration and fibroplasia of bile ducts were signilicantly more (P < 0.05) compared to those of controls. In portallymphnodes of the infected cattle the cortical hyperplasia, hyperplasia of tollicles. blast transformation, edema in sinuses, increase of histocytes and pigmentation were significantly higher (P< 0.05). There was a positive correlation between the changes of infected liver and related portal lymphnodes.