Effects of medetomidine with and without ketamine, and its reversal with atipamezole in goat

Abstract

Intramuscular administration of ketamine@ 5 mg/kg body weight in atropine (@0.1 mg/kg I/M) and medetomidine (@15 I/g/kg I/M) premedicated 12 male goats induced surgical anaesthesia in 10.62 ± 0.18 min. Anaesthesia lasted for 46.66 ± 4.40 min and the complete recovery occurred in 1·21.66±7.26 min. The administration ofmedetomidine @ 15 I/g/kg I/M in atropine @ 0.1 mglkg premedicated goats indhced sedation in 7.12±0.46 min for 40.83 ± 4.97 min with smooth and complete recovery occurring in II 0.00±5. 77 min. A significant (P<0.05) tachycardia followed by bradycardia, respiratory depression and hypothermia were seen after atropine-medetomidine or atropine- medetomidine - ketamine.Haemoglobin, PVC, TEC and TLC showed nonsignificant changes and the serum glucose significantly (P<0.05) increased up to 2 hr which returned near p-readministration level by 24 hr. Total proteins, serum urea nitrogen, creatinine, sodium and potassium remained unaltered. Atipamezole (15 I/g/kg IN) effectively reversed the sedative and anaesthetic effects with the mean arousal time of 0.68 ± 0.07 and 1.43 ± 0.08 min. The mean walking time 1.04 ± 0.09 in animals given atropine- medetomidine and 2.30 ± 0.41 min in animals atropirie- medetomidine- ketamine.