Disposition kinetics of ampicillin in Bubalus bubalis calves

Abstract

The pharmacokinetics of ampicillin after single i/v dose (10 mg/kg bw) was studied in a group of buffalo calves. The piasma drug concentration declined from 19.83±0.35 ug/ml to 0.22±0.01 up to 12hr. The mean values of kinetic parameters for t1/2a, t1/2B. vd_area: CI₈ and T/P ratio were 0.24±0.02 hr. 2.90±0.11 hr, 1.56±0.08 L/kg. 6.22±0.21 ml/kg/min, and 4.87±0.27 respectively. The mean values of K₁₂ , K₂₁ K₂ and K,/K21 were 1.17±0.13 hr^-1 . 0.47±0.02 hr^-1. 1.40±0.06 hr^-1 and 2.42±0.18 respectively. The per cent protein binding (in vitro) of ampicillin in the plasma of butfalo calves ranged from 19.25 to 28.09. Dosage regimen based on the kinetics of drug has been suggested for optimal clinical eflicacy.