Pharmacokinetics and urinary excretion of ciprofloxacin in crossbred cow calves

Abstract

The pharmacokinetics, urinary excretion and dosage regimen of ciprofioxaein after it's single intravenous administration of 5 mg.kg ^-1 was investigated in crossbred cow calves. At 1 min the concentration of ciprofloxacin in plasma was 10.3 ± 0.10 pg.ml which rapidly declined to 3.07 ± 0.02ug.ml^-1 at 10 min. The minimum therapeutic concentration (0.1 ugml^-1) in plasma was maintained lip to 6 hr. The elimination half life and volume of distribution were 3.75 ± 0.06 hr and 6.80 ± 0.15 L.kg -1. respectively. The distribution half life and AUC were 0.21 ± 0.003 hr and 3.98 ± 0.05ug.ml ^-1 hr respectiVely. The total body clearance (CIa) and tissue/plasma T/P) ratio werc 1.24 ± 0,02 L.kg'hr and 8.01 ± 0.22 respectively. Approximately 18% of the total administered dose ofciprofloxacin was recovered in urine within 24 hr after administration. A satisfactory intravenous dosage regimen of ciprotloxacin in cow calves would be 6 mg. kg ^-1 followed by 5 mg kg^-1 repeated at 12 hr intervals.