Disposition kinetics and distribution of ciprofloxacin in biological fluids of goats after intravenous administration

Abstract

Pharmacokinetics and distribution of ciprofloxacin in various biological fluids were undertaken post i. v. dose (4 mg. kg-1) in goats. Peak concentrations of 2.53 ± 0.07, 12.23 ± 0.82 and 198.50 ± 25.89 µg.ml·' were attained at 0.083, I and 1 hr in plasma, milk and urine respectively. The therapeutic concentration (≥0.12 I1g.ml·') were maintained up to 10, 12 and 36 hr, respectively, in plasma, milk and urine. Distribution half life (t_1/2α) and elimination half life (t,_1/2β) of 0.32 ± 0.05 and 4.71 ± 0.67 hr were noted in the present study. Vd of 4.22 ± 0.51 L.kg-1 obtained for ciprofloxacin in goat denotes its wide distribution in the body. The present investigation suggests a loading dose (D*) of 4.4 mg.kg-1 followed by a maintenance dose (Do) of 3.8 mg.kg-1 at the dosage interval (γ) of 12 hr for maintaining therapeutic concentration (MIC) of 0.12 µg.ml·-1.