Therapeutic efficacy of an indigenous drug formulation in experimental hepatopathy and nephropathy in goats

Abstract

Adult goats (19) of either sex were used to observe the efficacy of an ihdigenous drug formulation in hepatopathy and nephropathy by taking oxytetracycline-induced toxicity model. Animals were divided into groups 1,2 and 3. Groups 1 and 2 were divided into subgroups A and B, consisting of 4 animals each. Subgroups A and B received oxytetracycline (OTC) @ 25 mg/kg bwt and 40 mg/kg bwt respectively. Group 3 consisted of 3 animals and was maintained as healthy control. In addition to OTC, groups 1 and 2B received an indigenous drug formulation @ 10 g orally bid for 10 days. It consisted of Terminalia arjuna, Andrographis paniculata. Eclipta erecta. Trianthema decandra. Piper chaba. Saxifruga linguilata. Achyranthus aspera. Onosma bracteanum. Tinospora cardifolia. The toxicity of OTC and efficacy of indigenous drug formulation was assessed by haematological evaluations and biochemical evaluations consisting of liver function test and kidney function test. Indigenous drug was observed to be an effective adjuvant therapy for OTC-induced hepatopathy and nephropathy.