Pharmacokinetic disposition of cefotaxime in buffalo calves (Bubalus bubalis) following single intramuscular administration

Abstract

The pharmacokinetic disposition of cefotaxime was investigated in buffalo calves following its single intramuscular administration (10 mg.kg^-1). The peak plasma concentration ofcefotaxime at 20 min was 11.3±0.4S µg.ml^-1 which declined to 0.068±0.03 µg.ml-1 at 7 hr. The absorption half-life and elimination half-life were 0.145±0.047 and 1.24±0.07 hr respectively. The apparent volume of distribution and total body clearance were 1.17±0. 10L.kg^-1 and 0.67±0.09 L.kg^-1 hr respectively. Approximately 3.5% of the total administered drug was recovered in urine within 24 hr of its administration. An appropriate intramuscular dosage regimen for cefotaxime in buffalo calves would be 11 mg/kg repeated at 8 hr intervals.