Pharmacokinetics of suramin in uninfected and experimental Trypanosoma evansi infected buffalo calves

Abstract

The kinetic pattern of suramin was studied in uninfected and experimental Trypanosoma evansi infected (4.06 x 107 trypanosomes calf) in buffalo calves. The course of infection was chronic in experimental Tevansi infected buffalo calves and the infection was diagnosed by mice sub-inoculation test. The plasma level of suramin was 103.8± 1.63 and 160.5 ± 3.60 flg/ml at 1 min which declined to 8.29 ± 0.19 and 10.9 ± 0.88 Ilg/ml at 7 day in infected and uninfected buffalo calves, respectively, when suramin was administered @0.5 g/45 kg body weight. However, no concentration of the drug was found in plasma after 7 days post treatment. The pharmacokinetics ofsuramin following ilv administration was calculated by 3-compartmental open model. There was significant lower plasma levels up to 6 h and lower values of oc2' t'h ee2' AVC and Cpo in infected than uninfected buffalo calves.