Bacterial ghosts and their potential future applications-A mini review

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  • I HUSSAIN Division of Veterinary Microbiology and Immunology, Sher-E-Kashmir University of Agricultural Sciences and Technology, Shuhama, Srinagar, Jammu and Kashmir 190 006 India
  • S RAJKHOWA Senior Scientist, Animal Health Division, NRC on Pig, ICAR, Rani, Guwahati, Asom
  • D HASIN Division of Veterinary Physiology, Faculty of Veterinary Science and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology, Shuhama, Srinagar, Jammu and Kashmir 190 006 India
  • S IQBAL Division of Veterinary Physiology, Faculty of Veterinary Science and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology, Shuhama, Srinagar, Jammu and Kashmir 190 006 India


Adjuvant, Bacterial ghosts, Bio-adhesive, Carrier system, Multivalent vaccine, Safety, Tumor therapy


Bacterial ghosts system represents an emerging novel platform for antigens, nucleic acids and drug delivery. Bacterial ghosts are non-living Gram-negative bacterial cell envelopes devoid of cytoplasmic contents while maintaining their structural and morphological properties of native bacterial cells including surface antigens and bio-adhesive properties. They are generally produced by PhiX174 protein E-mediated lysis of Gram-negative bacteria. The intrinsic adjuvant properties of bacterial ghost preparations enhance immune responses against envelope bound antigens, including T-cell activation and mucosal immunity. These particles have envisaged both medical and veterinary applications for vaccination and treatment of various infectious diseases and tumors. The advantages of bacterial ghosts include the simplicity of the production method, safety, independence from the cold chain, and their intrinsic cellular and tissue tropic abilities.


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Review Article

How to Cite

HUSSAIN, I., RAJKHOWA, S., HASIN, D., & IQBAL, S. (2015). Bacterial ghosts and their potential future applications-A mini review. The Indian Journal of Animal Sciences, 85(12), 1283–1288.