Evaluation ofantioxidant activity ofOcimum sanctum and Emblica officinalis in rats

Abstract

The antioxidative potential of hydro-alcoholic extracts of Ocimum sanctum (tulsi) and Emblica officinalis (amla) was assessed in normal and immuno-compromised rats. The extracts were given @ 100 mg/kg b.wt. daily po for 21 days and cyclophosphamide was administered intraperitonially @50 mg/kg once at the start of expeiriment. Th~ I!~id peroxidation (LPG), reduced glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activIties were assessed. On the basis ofresults, it was concluded that Ocimum sanctum and Emblica officinalis both are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential, however, Emblica officinalis was superior to Ocimum sanctum.