Comparative evaluation of endogenous and exogenous creatinine clearance for assessment of glomerular filtration rates in buffalo calves

Abstract

Female buffalo calves (4) were studied for renal clearance of endogenous and exogenous (creatinine infused @ 15.0 mg/ kg and 40.0 mg/kg body wt) creatinine clearance and compared with inulin clearance. Both dose rates provided better estimates with respective values of glomerulal filtration rates (GFR) 187.7±9.0, 211.O±6.6 ml/min. Respective values for endogenous creatinine and insulin clearance were 203.0±8.8 and 180.1±7.0 ml/min. Creatinine clearance at low dose rate level gave better significant positive correlation (r=0.845)compared to higher dose rate level (r=0.187),which was non-significant. Data indicated that infusion of exogenous creatinine at 15.0 mg/kg body weight could be used to assess glomerular filtration rate in buffalo calves in place of more tedious and cumbersome inulin clearance.