Effect of synergistic antioxidant against salinomycin toxicity in broiler chicken
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Keywords:
Antioxidants, Broilers, Oxidative damage, Salinomycin, Synergistic antioxidantAbstract
Salinomycin toxicity was evaluated at therapeutic (6O ppm) and toxic (120 ppm) dose levels and the efficacy of a synergistic antioxidant (SA) was assessed for prophylactic and therapeutic management of salinomycin toxicity in broiler chicks. Day-old male broiler chicks were randomly divided into 7 groups consisting of 6 chicks each. Groups 1, 2 and 3 wercemaintained as control, therapeutic dose control (60 ppm) and toxic dose control (120 ppm) respectively. Groups 4 and 5 were fed on feed containing salinomycin @ 60 and 120 ppm, respectively, along with SA @ 125 mg/kg of feed. Groups 6 and 7 were fed on feed containing salinomycin @120 ppm for the first 5 weeks of study for induction of ionophore toxicity. For the following 2 weeks, group 6 received SA @125 mg/kg of feed and group 7 was fed on feed containing salinomyocin @ 120 ppm along with SA @ 125 mg/kg of feed. Body weights and FCR were recorded at weekly intervals revealed a significant decrease, while the activities of antioxidant enzymes (glutathione peroxidase, glutathione reductase and catalase) were significantly increased and glutathione levels decreased significantly (P<0.01) in toxic controls as compared to groups 1,2, 4 and 5. The biochemical parameters such as AST, total proteins, total cholesterol, triglycerides, LDL, urea, creatinine and BUN were significantly elevated in toxic controls, whereas HDL level was significantly (P<O.O1) lowcrcd us compared to goups 1,2,4 and 5. Following antioxidant therapy all serobiochemical parameters of groups 6 and 7 were revived to normal. Thus, it is concluded that SA is useful in feed to avoid any accidental ionophore toxicity.Downloads
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Submitted
2011-08-24
Published
2005-06-05
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The copyright of the articles published in The Indian Journal of Animal Sciences is vested with the Indian Council of Agricultural Research, which reserves the right to enter into any agreement with any organization in India or abroad, for reprography, photocopying, storage and dissemination of information. The Council has no objection to using the material, provided the information is not being utilized for commercial purposes and wherever the information is being used, proper credit is given to ICAR.
How to Cite
Kamashi, K., Reedy, A. G., Reddy, K. S., & Reddy, V. R. (2005). Effect of synergistic antioxidant against salinomycin toxicity in broiler chicken. The Indian Journal of Animal Sciences, 75(6). https://epubs.icar.org.in/index.php/IJAnS/article/view/9600