IDENTIFICATION OF BIOACTIVE COMPOUNDS WITH ANTICANCER PROPERTIES IN Pleurotus florida
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Keywords:
Anticancer, bioactive, mushrooms, Pleurotus florida.Abstract
Pleurotus florida mushrooms have gained immense popularity among nutritionists owing to
their medicinal and nutritional properties. In recent times, the consumption of these mushrooms is
tremendously increased due to their health benefits. Besides the nutritional qualities,Pleurotus florida
possess bioactive compounds of high and low molecular weight compounds.
The bioactive fractions were processed using the Shimadzu GC-MS (Model no. Qp2010S) gas
chromatography-mass spectrometry method in 2020-21. On comparing the mass spectra and retention
indices of the compounds on mushroom extract using ethanol, 14 bioactive compounds were identified.
In vitro cytotoxic analysis of the mushroom extract revealed that the mushroom extract possessed
promising anticancer effects,and the main biologically active substances of mushrooms may be
responsible for direct cytotoxicity towards cancer cell lines such as DLA and EAC cell lines. The
percentage of cancer live cells decreases with an increase in the concentration of the sample.
References
Alam,N., Amin, R and Khan., A.2009.
Comparative effects of oyster mushrooms
on lipid profile, liver and kidney function in
hypercholesterolemic rats. Mycobiology
(1): 37-42. http://dx.doi.org/10.4489/
MYCO.2009.37.1.037 PMID: 23983505.
Bajaj, M., Vadhera, S., Brar, A.P and Soni, G.
L.2004. Role of Oyster mushroom
(Pleurotus florida) as hypocholesterolemic
/ antiatherogenic agent. Indian Journal of
Experimental Biology.35:451.
Beetz, A. and Kustudia, M.2004.Mushroom
cultivation and marketing: Horticulture
production guide, ATTRA Publication
IP087.
Chandha, K.L and Sharma, S. R.1995. Advances
in Horticulture mushroom. Malhotra
Publication House, New Delhi.13:649.
Chang, S.T and Miles, P.G. 2004.Mushrooms:
Cultivation, nutritional value, medicinal
effects, and environmental impact.2nd
Edition. CRC Press. Boca Raton. pp.451.
Chirinang, P and Intrapichet, K.O. 2009. Amino
acid and antioxidant properties of the
oyster mushrooms, Pleurotus ostreatus
and Pleurotus Sojercaju. Science Asia.
:326-331.
Chiroro, C.K. 2004. Mush World website (online).
Available:http://mushroomtime.org/
w p c o n t e n t / u p l o a d s / 2 0 1 4 / 0 6 / 0 2 -
Mushroom-Growers-Handbook-1-Oyster-
Mushroom-Cultivation-MUSHWORLD.Pdf.
Cohen, R., Persky, L and Hadar, Y. 2002.
Biotechnological applications and potential
of wood degrading mushrooms of the
genus Pleurotus. Applied Microbiology and
Biotechnology. 58:582-594.
Corrêa, R. C. G., Brugnari, T and Bracht, A. 2016.
Biotechnological, nutritional, and
therapeutic uses of Pleurotus spp. (oyster
mushroom) related with its chemical
composition: A review on the past decade
findings. Trends in Food Science and
technology. 50: 103-117.
Deepalakshmi, K and Mirunalini, S.2014.
Pleurotus ostreatus: an Oyster mushroom
with nutritional and medicinal properties.
Journal of Biochemical Technology.
(2):718-726.
Facchini, J.M., Alves, E. P. Aguilera, C., Gern, R.
M. M.,Silveira, M.L.L.,Wisbeck,E and
Furlan,S.A. 2014. Antitumor activity of
Pleurotus ostreatus polysaccharide
fractions on Ehrlich tumor and Sarcoma
International Journal of Biological
Macromolecules. 68:72-77.
Guillamón, E., García-Lafuente, A., Lozano, M.D.,
ìArrigo, M., Rostagno, M.A., Villares, A and
Martínez,J.A. 2010. Edible mushrooms:
Role in the prevention of cardiovascular
diseases. Fitoterapia. 81:715–723.
Hussain, T. 2001. Growing mushroom. A new
horizon in agriculture. Mushroom Journal.
:23-26.
Imtiaj, A and Rahman, S.A.2008. Short note (Nota
Corta) Economic viability of mushroom
cultivation to poverty reduction in
Bangladesh (Viabilidad Economica Del
cultivo De). pp.26-27.
Jayakumar, T., Thomas, P.A., Sheu, J.R, and
Geraldine, P. 2011. In-vitro and in-vivo
antioxidant effects of the Oystermushrooms Pleurotus ostreatus. Food
Research International. 44:851-861.
Jones, S and Janardhanan, K.K. 2000.
Antioxidant and antitumor activity of
Ganoderma lucidum (Cart. Fr.) P.Karst.-
Reishi (Aphyllophoro mycetidae) from
South India. International Journal of
Medicinal Mushrooms. 2:195-200.
Jose,N and Janardhanan,K.K.2000. Antioxidant
and antitumor activity of Pleurotus florida.
Current Science.79:941-943.
Khan, M. A and Tania, M.2012.Nutritional and
medicinal importance of Pleurotus
mushrooms: An overview. Food Reviews
International.28(3):313-329.
Khatun,S., Islam,A., Cakilcioglu,U and Chatterjee,
N.C.2012.Research on mushrooms as a
potential source of nutraceuticals. A review
of the Indian perspective. American Journal
of Experimental Agriculture.2(1):47-73.
Kong, W.S. 2004. Description of commercially
important Pleurotus species In: Choi, K.W.,
(Editor). Mushroom growers handbook.
Seoul (South Korea): Oyster Mushroom
Cultivation. Mushroom World. pp. 54–61.
Kudahewa, D.D. Abeytunga DTU and
Ratnasooriya, W.D.2008. Antinociceptive
activity of Pleurotus cystidiosus an edible
mushroom in rats. Pharmacognosy
Magazine. 4:37-41.
Kues, U and Liu, Y. 2000. Fruiting body
production in basidiomycete. Applied
Microbiology and Biotechnology. 54:141-
Lindequist, U., Niedermeyer, T.H., Julich, W.D.
The pharmacological potential of
m u s h r o o m s . E v i d e n c e - b a s e d
complementary and Alternative Medicine.
(3): 285-299.
Maiti, S., Mallick, S.K., Bhutia, S.K., Behera, B.,
Mandal, M and Maiti, T.K. 2011. Antitumor
effect of Culinary medicinal Oyster
mushroom Pleurotus ostreatus (Jacq:Fr.)
P. Kumm derived protein fraction on tumorbearing
mice models. International Journal
of Medicinal Mushroom.13:427-440.
Morris H.J., Beltran Y., Llaurado G., Batista P.L.,
Perraud-Gaime I and Garcia N. 2017.
Mycelia from Pleurotus spp.(oyster
mushroom): A new wave of antimicrobials,
anticancer and antioxidant bio ingredients.
International Journal of Phytocosmetics
and Natural Ingredients. 2:14, DOI:
15171/ijpni.14.
Patel, S and Goyal, A. 2012. Recent
developments in mushroom as anti-cancer
therapeutics: A review. Biotechnology. 2:1-
PateL, Y., Naraian, R and Singh, V.K.2012.
Medicinal properties of Pleurotus species
(oyster mushroom): A review word. Journal
of Fungal Plant Biology. 3(1):1-12.
Sala Uddin,G.M., Sarwar Hossain, M., Monirul
Islam, M., Asaduzzaman, M., Jahan
Bulbul, I and Ruhul Amin, M. 2015.
Evaluation of antimicrobial, antioxidant,
and cytotoxic properties of Pleurotus
ostreatus Mushroom. International
Research Journal of Biological
Sciences.4:29-33.
Stachowiak, B and Regula J. 2012. The healthpromotion
potential of edible macromycetes
under special consideration of
polysaccharides: A review. European Food
Research and Technology. 234: 369-380.
Synytsya, A., Mickova K., Jablonsky I., Slukova
M and Copicova J. 2008. Mushrooms of
the genus Pleurotus as a source of dietary
fibers and glucans for food supplements.
Czech Journal of Food Science. 26(6):
-446.
Takaku, T., Kimura, Y and Okuda, H. 2001.
Isolation of an antitumor compound from
Agaricus blazei Murill & its mechanism of
action. Journal of Nutrition. 131:1409-
Tong, H., Xia, F., Feng, K., Sun, G., Gao, X and
Sun, L. 2009. Structural characterization
and in-vitro antitumor activity of a novel
polysaccharide isolated from the fruiting
bodies of Pleurotus ostreatus. Bioresource
Technology. 100: 1682-1686.
Wasser, S.P. 2014. Medicinal mushroom science:
Current perspectives,advances, evidence,
and challenges. Biomedical Journal. 35(6):
–528.
Wasser, S.P. 2011. Current findings, future trends
and unsolved problems in studies of
medicinal mushrooms.Applied
Microbiology and Biotechnology. 89:1323-
Wolff, E.R.S.., Wisbeck, E., Silveira, M.L.L.,
Gern,R.M.M., Pinho, M.S.L and Furlan,
S.A. 2008. Anti-microbial and
antineoplastic activity of Pleurotus
ostreatus. Applied Biochemistry and
Biotechnology. 151: 402-412.
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