Astaxanthin – King of antioxidants as immune modulator and anti-inflammatory for enhancing productive performance and health of animals
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Keywords:
Astaxanthin, Bovines, Heat stress, Immunity, InflammationAbstract
Astaxanthin is the potent antioxidant predominantly found in living organisms that are present in marine environment. It is known as “King of antioxidant†or “Super vitamin E†because of its potent antioxidant property. Antioxidant property of astaxanthin known to modulate different biological activity relating to antioxidant defence system, inflammation, immunity and ameliorating adverse effect of oxidative stress during summer season. Its use has been found in improving both male and female reproductive health and production performance of bovines. Astaxanthin helps in hastening of sexual maturity, improving sperm quality, increasing fertility and better development of embryos. It is considered as one of the essential feed additive in combating the adverse effect of climate change on production performance of animals. This review mainly focuses on source, structure and use of astaxanthin as an antioxidant, anti-inflammatory, immune stimulator and for improving productive performance of bovines.
References
Amar EC, Kiron V, Satoh S, Watanabe T (2001) Influence of various dietary synthetic carotenoids on bio defence mechanisms in rainbow trout, Oncorhynchus mykiss (Walbaum). Aquac Res 32: 162-173
Ambati RR, Phang SM, Ravi S, Aswathanarayana, RG (2014) Astaxanthin: sources, extraction, stability, biological activities and its commercial applications - a review. Mar Drugs 12: 128-152
Augusti PR, Quatrin A, Somacal S, Conterato GM, Sobieski R, Ruviaro AR, and Emanuelli T (2012) Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits. J Clin Biochem Nutr 51: 42-49
Biswal S (2014) Oxidative stress and astaxanthin: The novel supernutrient carotenoid. Int J Res Health Allied Sci 3: 147
Buesen R, Schulte S, Strauss V, Treumann S, Becker M, Groters S, Van Ravenzwaay B (2015) Safety assessment of [3S, 32 S]-astaxanthin–Subchronic toxicity study in rats. Food Chem Toxicol 81:129-136
Choi YE, Yun YS, Park JM (2002) Evaluation of factors promoting astaxanthin production by a unicellular green alga, Haematococcus pluvialis, with fractional factorial design. Biotechnol Prog 18: 1170-1175
Comhaire FH, Garem YE, Mahmoud A, Eertmans F, Schoonjans FRANK (2005) Combined conventional/antioxidant “Astaxanthin†treatment for male infertility: a double blind, randomized trial. Asian J Androl 7: 257-262
Cyanotech 2000 NatuRose®. Available at www.cyanotech.com/ html/asta/natu/naturose.html [accessed 12 December 2007]
Darachai J, Piyatiratitivorakul S, Menasveta P (1999) Effect of astaxanthin on growth and survival of Penaeus monodon larvae. In Proceedings of the 37th Kasetsart University Annual Conference 36-41
Do LTK, Luu VV, Morita Y, Taniguchi M, Nii M, Peter AT, Otoi T (2015) Astaxanthin present in the maturation medium reduces negative effects of heat shock on the developmental competence of porcine oocytes. Reprod Biol 15: 86-93
Fang YI, Zhong R, Chen L, Feng C, Sun H, Zhou D (2015) Effects of astaxanthin supplementation on the sperm quality and antioxidant capacity of ram semen during liquid storage. Small Rumin Res 130: 178-182
Farzan M, Chamani M, Varnaseri H (2014) The antioxidant effect of astaxanthin on quantitative and qualitative parameters of bull sperm. Indian Journal of Foundamental and Applied Life Sciences 4: 425-430
Fassett RG, Coombes JS (2011) Astaxanthin: a potential therapeutic agent in cardiovascular disease. Mar Drugs 9(3): 447-465
Foss P, Renstrøm B, Liaaen-Jensen S (1987) Natural occurrence of enantiomeric and Meso astaxanthin 7"-crustaceans including zooplankton. Comp Biochem Physiol B 86: 313-314
Goto S, Kogure K, Abe K, Kimata Y, Kitahama K, Yamashita E, Terada H (2001) Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochim Biophys Acta Biomembr 1512: 251-258
Guerin M (2001) Pigmentation of red seabream with natural astaxanthin derived from the alga Haematococcus pluvialis: comparison with synthetic astaxanthin. In Aquaculture 2001 conference, Lake Buena Vista, Florida, January 2001. World Aquaculture Society
Guerin M, Huntley ME, Olaizola M (2003) Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 21: 210-216
Hansen KB, Tauson AH, Inborr J (2001) Effect of supplementation with the antioxidant astaxanthin on reproduction, pre-weaning growth performance of kits and daily milk intake in mink. J Reprod Fertil Suppl 57: 331-334
Higuera-Ciapara I, Felix-Valenzuela L, Goycoolea FM (2006) Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr 46: 185-196
Holtin K, Kuehnle M, Rehbein J, Schuler P, Nicholson G, Albert K (2009) Determination of astaxanthin and astaxanthin esters in the microalgae Haematococcus pluvialis by LC-(APCI) MS and characterization of predominant carotenoid isomers by NMR spectroscopy. Anal Bioanal Chem 395: 1613
Hormozi M, Ghoreishi S, Baharvand P (2019) Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells. Artif Cells Nanomed Biotechnol 47: 891-895
Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H (2006) Astaxanthin, a carotenoid with potential in human health and nutrition. J. Nat. Prod 69: 443-449
Ispada J, Rodrigues TA, Risolia PHB, Lima RS, Gonçalves DR, Rettori D, Paula-Lopes FF (2018) Astaxanthin counteracts the effects of heat shock on the maturation of bovine oocytes. Reprod Fert Dev 30: 1169-1179
Jang HY, Ji S J Kim, YH Lee, HY Shin, JS, Cheong HT, Yang BK (2010) Antioxidative effects of astaxanthin against nitric oxide induced oxidative stress on cell viability and gene expression in bovine oviduct epithelial cell and the developmental competence of bovine IVM/IVF embryos. Reprod Domest Anim 45: 967-974
Jyonouchi H, Hill RJ, Tomita Y, Good RA (1991) Studies of immunomodulating actions of carotenoids. I. Effects of â carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression in in vitro culture system. Nutr Cancer 16: 93-105
Kamada H, Akagi S, Watanabe S (2017) Astaxanthin increases progesterone production in cultured bovine luteal cells. J Vet Med Sci 17-0044
Kumar S (2018) Influence of astaxanthin supplementation on growth performance, immunity and antioxidant status in heifers during summer season (Doctoral dissertation, National Dairy Research Institute, Karnal)
Kumar S, Singh SV (2019) Inhibition of NF-êB signaling pathway by astaxanthin supplementation for prevention of heat stress–induced inflammatory changes and apoptosis in Karan Fries heifers. Trop Anim Health Pro 51: 1125-1134
Kumar S, Singh SV (2020) Influence of astaxanthin supplementation on attainment of puberty and lipid peroxidation in Sahiwal and Karan Fries (Holstein× Tharparkar) heifers during summer season. Biol Rhythm Res 51: 15-28
Kuroki T, Ikeda S, Okada T, Maoka T, Kitamura A, Sugimoto M, Kume S (2013) Astaxanthin ameliorates heat stress-induced impairment of blastocyst development In Vitro:–astaxanthin colocalization with and action on mitochondria. J Assist Reprod Gen 30: 623-631
Lara JJ, Economou M, Wallace AM, Rumley A, Lowe G, Slater C, Lean ME (2007) Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects. Atherosclerosis 193: 213-221
Lee DH, Kim CS, Lee YJ (2011) Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. â€Food Chem. Toxicol 49: 271-280
Lee E, Kim D (2018) Effects of astaxanthin on miniature pig sperm cryopreservation. Biomed Res Int. doi.org/10.1111/and.13389.
Liu BH, Lee YK (2003). Effect of total secondary carotenoids extracts from Chlorococcum sp. on Helicobacter pylori-infected BALB/c mice. Int Immunopharmacol 3: 979-986
Liu X, Osawa T (2007) Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer. Biochem Biophys Res Commun 357: 187-193
McNulty H, Jacob RF, Mason RP (2008) Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Am J Cardiol 101: S20-S29
Miki W (1991) Biological functions and activities of animal carotenoids. Pure Appl Chem 63: 141-146
Mortazavi M, Salehi I, Alizadeh Z, Vahabian M and Roushandeh AM (2014) Protective effects of antioxidants on sperm parameters and seminiferous tubules epithelium in high fat-fed rats. J Reprod Infertil 15: 22
Naguib YM (2000) Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem 48: 1150-1154
Namekawa T, Ikeda S,Sugimoto M, Kume S (2010) Effects of astaxanthin containing oil on development and stress related gene expression of bovine embryos exposed to heat stress. Reprod Domest Anim 45(6): e387-e391
Olson J A (2004) Carotenoids: absorption, transport, and metabolism of carotenoids in humans. Pure Appl Chem 66: 1011-1016
Pan CH, Chien YH, Hunter B (2003) The resistance to ammonia stress of Penaeus monodon, Fabricius juvenile fed diets supplemented with astaxanthin. J Exp Mar Biol Ecol 297: 107-118
Park JS, Chyun JH, Kim YK, Line LL, Chew BP (2010) Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr. Metab 7: 18
Pashkow FJ, Watumull DG, Campbell CL (2008) Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am J Cardiol 101: 58-S68
Priyadarshini L (2017) Immunity, antioxidant, energy status and production performance in pre and post-partum Murrah buffaloes during summer and winter seasons (Doctoral dissertation, National Dairy Research Institute; Karnal)
Priyadarshini L, Aggarwal A (2018) Astaxanthin inhibits cytokines production and inflammatory gene expression by suppressing IêB kinase-dependent nuclear factor êB activation in pre and postpartum Murrah buffaloes during different seasons. Vet World 11: 782
Putman M (1992) A review of the nature, function, variability, and supply of pigments in salmonid fish. EAS Special Publication
Rao AR, Sindhuja HN, Dharmesh SM, Sankar KU, Sarada R, Ravishankar GA (2013) Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis. ýJ Agric Food Chem 61: 3842-3851
Salamon S, Maxwell WMC (2000) Storage of ram semen. Anim. Reprod Sci 62: 77-111
Sandmann G (1994) Carotenoid biosynthesis in microorganisms and plants. In EJB Reviews. Springer, Berlin, Heidelberg 129-146
Somagond YM, Singh S, Deshpande A, Sheoran P, Chahal VP (2020) Physiological responses, energy metabolites and prolactin levels of buffaloes supplemented with dietary astaxanthin, prill fat and their combination during heat stress. Indian J Anim Sci 90: 55-60
Somagond YM, Singh SV, Deshpande A (2019) Effect of dietary supplementation of astaxanthin, prill fat and combination on stress indicators, milk yield and composition during heat stress in buffaloes. Biol Rhythm Res 1-11.doi.org/10.1080/09291016.2019.1658426
Soren S, Singh SV (2018) Semen quality, lipid peroxidation and expression of mitochondrial gene in ejaculated sperm of Karan Fries (Tharparkar x Holstein Friesian) bulls supplemented with astaxanthin. Indian J Anim Sci 88: 1346-1352
Soren S, Singh SV, Kumar S (2017) Effect of astaxanthin supplementation on semen (Karan Fries Bulls) storage at 5 C. Int J Curr Microbiol Appl Sci 6: 23-28
Speranza, L, Pesce M, Patruno A, Franceschelli S, Lutiis MAD, Grilli A, Felaco M (2012) Astaxanthin treatment reduced oxidative induced pro-inflammatory cytokines secretion in U937: SHP-1 as a novel biological target. Mar Drugs 10: 890-899
Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta Mol Basis Dis 1740: 101-107
Takaichi S, Matsui K, Nakamura M, Muramatsu M, Hanada S (2003) Fatty acids of astaxanthin esters in krill determined by mild mass spectrometry. Comp Biochem Physiol B Biochem Mol Biol 136: 317-322
Tang X, Liu B, Wang X, Yu Q, Fang R (2018) Epidermal growth factor, through alleviating oxidative stress, protect IPEC-J2 cells from lipopolysaccharides-induced apoptosis. Int J Mol Sci 19: 848
Tizkar B, Kazemi R, Alipour A, Seidavi A, Naseralavi G, Ponce-Palafox JT (2015) Effects of dietary supplementation with astaxanthin and â-carotene on the semen quality of goldfish (Carassius auratus). Theriogenology 84: 1111-1117
Tripathi DN, Jena GB (2008) Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells. Toxicology 248: 96-103
Yang Y, Seo JM, Nguyen A, Pham TX, Park HJ, Park Y, Lee J (2011) Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice. J Nutr 141: 1611-1617
Young FM, Luderer WB, Rodgers RJ (1995) The antioxidant â-carotene prevents covalent cross-linking between cholesterol side-chain cleavage cytochrome P450 and its electron donor, adrenodoxin, in bovine luteal cells. Mol Cell Endocrinol 109: 113-118
Yuan JP, Peng J, Yin K, Wang JH (2011) Potential health promoting effects of astaxanthin: A high value carotenoid mostly from microalgae. Mol Nutr Food Res 55: 150-165